https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39803 1 nanoprobe for noninvasive visualization of biological events. However, the structure–relaxivity relationship and regulatory mechanism of UFNPs remain elusive. Herein, we developed chemically engineered 3.8 nm ZnxFe₃–xO4@ZnxMnyFe_3–x–x–yO₄ (denoted as Zn_xF@Zn₄Mn₄F) nanoparticles with precise dopants control in both crystalline core and disordered shell as a model system to assess the impact of dopants on the relaxometric properties of UFNPs. It is determined that the core–shell dopant architecture allows the optimal tuning of r1 relaxivity for Z_0.40.4F@Zn_0.40.4Mn_0.2F up to 20.22 mM^–1 s^–1, which is 5.2-fold and 6.5-fold larger than that of the original UFNPs and the clinically used Gd-DTPA. Moreover, the high-performing UFNPs nanoprobe, when conjugated with a targeting moiety AMD3100, enables the in vivo MRI detection of small lung metastasis with greatly enhanced sensitivity. Our results pave the way toward the chemical design of ultrasensitive T₁ nanoprobe for advanced molecular imaging.]]> Wed 10 Aug 2022 13:11:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52820 Tue 14 Nov 2023 11:54:22 AEDT ]]>